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Prof Karine CLEMENT

Institution: 
INSERM

Tasks in the project:

Karine Clément is the Coordinator of the METACARDIS and leader of WP3. 

WP1 & WP3: Her team will contribute to the coordination, collection and phenotyping of patients for low-grade inflammation -adipose tissue immunohistochemistry circulating cytokines, cell sorting for monocytes. Also to the study of the impact of faecal water on adipose cell biology in human cell models. Her team will also contribute to bioinformatics analysis of lifestyle factors in interaction with host biology in collaboration with Danone Research .

Biography:

Prof Karine Clement is a full professor of Nutrition, Division of Cardiometabolism, Pitié-Salpêtrière Hospital and at Paris 6 Pierre et Marie Curie university in Paris. Since 2011 she is director of the Center of Excellence ICAN (Institute de Cardiometabolism and Nutrition) which is dedicated to innovative care, research and training in the field of cardiology and metabolic diseases. This institute aims at developing personalized medicine in the field of cardiometabolic diseases. 

Karin Clement’s team (Nutriomique) has been involved in genetic and functional genomics aspects of human obesity. Her work led to the identification of monogenic forms of obesity (Leptin receptor and MC4R mutations) and to several genetic risk factors in common obesity. She contributed to more than 200 international publications, reviews and many international conferences in the field. She performed a post-doctoral fellowship at Stanford University, CA, USA where she acquired competencies in gene profiling approaches applied to complex diseases (1999-2000). In 2001 she obtained a young INSERM “Avenir” team focused on the characterization of patterns of gene expression induced by environmental perturbations. Her group showed notably that inflammatory and remodeling genes in human adipose tissue are modulated by weight variation in parallel to macrophage infiltration changes. Deeper insight into mechanisms is now undertaken. In addition, the team is exploring the link between environment changes and functional modifications in the adipose tissue. The gut microbiota is of evidence a key actor of this link. She is a member and expert of several national and international scientific committees in obesity and metabolism and contributes to several European Networks in genetics and functional genomics (Diogenes, Hepadip, ADAPT, FLIP).

Main publications:

  1. Kong LC, Tap J, Aron-Wisnewsky J, Pelloux V, Basdevant A, Bouillot JL, Zucker  JD, Doré J, Clément K. Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue  genes. Am J Clin Nutr. 2013 May 29. [Epub ahead of print] PubMed PMID: 23719559. 
  2. Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, Mariat D,  Corthier G, Doré J, Henegar C, Rizkalla S, Clément K. Differential adaptation of  human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes. 2010 Dec;59(12):3049-57.  doi: 10.2337/db10-0253. Epub 2010 Sep 28. PubMed PMID: 20876719; PubMed Central  PMCID: PMC2992765. 
  3. Aurélie Cotillard, Sean P. Kennedy, Ling Chun Kong, Edi Prifti, Nicolas Pons Emmanuelle Le Chatelier, Mathieu Almeida, Benoit Quinquis, Florence Levenez, Nathalie Galleron, Sophie Gougis, Salwa Rizkalla, Jean-Michel Batto, Pierre Renault, ANR MicroObes Consortium Joel Doré Jean-Daniel Zucker, Karine Clément, Stanislav Dusko Ehrlich;  Dietary intervention impact on gut microbial gene richness. Nature, 2013 in press 
InstNumber: 
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